Ø Pharmacokinetic/Toxicokinetic studies: In-vivo pharmacokinetics/toxicokinetics (bioavailability, excretion, tissue
distribution and dose proportionality studies) of xenobiotics in preclinical
animals using different route of administration (Oral, I.V., I.P., I.M. etc.).
Ø Bio-analysis: Method
development and validation for xenobiotics quantification in different matrices
(e.g. blood, plasma, urine, tissues, water and food commodities etc.) using
UPLC, LC-MS/MS and GC-MS/MS.
Ø In-vitro metabolism: Metabolic
stability, metabolite identification, CYP450/UGTs phenoytping & inhibition
studies of xenobiotics using recombinant enzymes/microsomes/S9
fraction/hepatocytes as test system.
Ø Interaction studies:
Pesticide-drug, drug-drug and food-drug interaction studies using in-vitro test
systems and in-vivo prediction using mathematical models.
Ø Human pharmacokinetics prediction: Allometry scaling and in-vitro in-vivo extrapolation (IVIVE) using
in-vitro and in-vivo preclinical data for predicting the
pharmacokinetics/toxicokinetics in humans.
Ø Risk assessment: Integration of
species difference in metabolism & toxicokinetics, and PBPK modelling for
assessing the risk of environmental toxicants/toxins exposure on human health.
ØPesticide Residue Analysis: Multi pesticide residues
determination in different food commodities such as vegetables, fruits, cereals
and pulses as per NABL.