Bone marrow is a complex tissue composed of multiple somatic cells  such as adipocytes, osteoblasts, endothelial cells, reticular cells, macrophages, fibroblasts, and two stem cell populations - hematopoietic and mesenchymal. In this complex environment are present small pockets, known as niche, which harbors these two stem cell populations. The intricate cross-talk between the cells, extracellular matrix, and secretory factors like chemokines, growth factors and exosomes, plays an important role in maintaining normal homeostasis. Thus, any kind of stress due to exposure to environmental pollutant or drug can disturb the homeostatic balance and can contribute to disease condition. 

Keeping this in mind, the research focus of the lab are:

• Effect of xenobiotics on mesenchymal stem cell differentiation and its underlying mechanism.

• Role of osteoblast in conferring chemoprotection to Acute Myeloid Leukemia

• Verma J, Rai AK, Satija NK*. Autophagy perturbation upon acute pyrethroid treatment impacts adipogenic commitment of mesenchymal stem cells. Pestic Biochem Physiol. 2023;195:105566. 

• Rai AK, Satija NK*. A comparative analysis of daunorubicin and its metabolite daunorubicinol interaction with apoptotic and drug resistance proteins using in silico approach. J Biomol Struct Dyn. 2023;41:10737-10749.

• Verma NK, Kar AK, Singh A, Jagdale P, Satija NK, Ghosh D, Patnaik S. Control Release of Adenosine Potentiate Osteogenic Differentiation within a Bone Integrative EGCG-g-NOCC/Collagen Composite Scaffold toward Guided Bone Regeneration in a Critical-Sized Calvarial Defect. Biomacromolecules. 2021;22:3069-3083.

• Das N, Kumar A, Roy SK, Satija NK, Gopal RR. Bare plasmonic metal nanoparticles: synthesis, characterisation and in vitro toxicity assessment on a liver carcinoma cell line. IET Nanobiotechnology 2020;14:851-857.

• Kumar A, Das N, Satija NK, Mandrah K, Roy SK, Rayavarapu RG. A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent. Nanomaterials (Basel). 2019;10:45.

• Singh VK, Arora D, Satija NK, Khare P, Roy SK, Sharma PK. Intricatinol synergistically enhances the anticancerous activity of cisplatin in human A549 cells via p38 MAPK/p53 signalling. Apoptosis. 2017;22:1273-1286.

• Rai AK,  Satija NK*. (2021) Oxidative Stress Targeted Therapies for the Treatment of Acute Myeloid Leukemia. In: Chakraborti S., Ray B.K., Roychowdhury S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. (doi.org/10.1007/978-981-15-4501-6_122-1)

• Rai AK,  Satija NK*. (2021) Importance of targeted therapies in acute myeloid leukemia. In: Hasija Y (ed) Translational Biotechnology: A Journey from Laboratory to Clinics. Academic Press (Elsevier), United Kingdom. (doi.org/10.1016/B978-0-12-821972-0.00017-4)