17.fodkl'khy pwgksa esa ySECMk& lkbyksfFkzu dh efLr"d O;ogkj lEcfU/kr fo"kkDrrk esa MksikfeuftZd ,oa fljSVksuftZd iz.kkfy;ksa dh Hkkxhnkjh |
ySECMk& lkbyksfFkzu ¼f}rh; ih<+h la'ysf"kr O;kid mi;ksx ls euq"; esas tksf[ke dkQh vklUu gSA orZeku v/;;u bl ckr dh tkap gsrq fd;k x;k gS fd ySECMk lkbyksfFkzu efLr"d dh MksikfeuftZd vkSj lsjksVksuftZd iz.kkfy;ksa rFkk muds dk;ksZa dks fdl izdkj ls izHkkfor djrk gSA ySECMk lkbyksfFkzu ¼1-0 feyhxzke@fdyksxzke ;k 3-0 feyhxzke@fdyksxzke 'kjhj ds otu½ dk iksLV& ySDVs'kuy izn'kZu (PD22 ls PD49 ds e/;½ eksVj xfrfof/k esa ,d egRoiw.kZ deh djrk gSA lkFk gh pwgksa PD50 ij jksVk&jkWM ds izn'kZu ij fu;a=.k dh vis{kk vf/kd deh Hkh djrk gSA ySECMk lkbyksfFkzu lekosf'kr pwgksa esa eksVj xfrfof/k esa deh] PD65 izdVu ds dh okilh ds ckn 15 fnuksa rd jgrh gS] tcfd jksMk&jkWM ds izn'kZu eas lq/kkj dh ,d izo`fRr lh ikbZ xbZ gSA 3H-spiperone ds ca/ku esa deh dks Mksikehu D2 fjlsIVlZ }kjk dkWilZ fLVª,Ve dks yscy djus ds fy, mi;ksx fd;k tkrk gSA dkWilZ fLVª,Ve] Vkbjkslhu gkbMªkfDlyst (TH) - immunoreactivity vkSj TH izksVhu esa deh dk izn'kZu djrk gS ftls ySECMk& lkbZgSyksfFkzu lekosf'kr pwgksa esa PD50 vkSj PD65 fu;a=.k ds rqyuk esa ns[kk tk ldrk gSA ySEck&lkbyksfFkzu dh ,d vf/kd ek=k ¼3-0 feyhxzke@fdyksxzke½ ls lekosf'kr pwgksa esa vR;kf/kd ifjorZu dkss ns[kk tkrk gS tksfd izn'kZu ds 15 fnuksa ckn rd O;kIr jgrh gSA ifj.kke fodkl'khy pwgksa esa ySECMk& lkbyksfFkzu ds vlj dks iznf'kZr djrk gS rFkk ;g crkus esa enn djrk gS fd striatal MksikfeuftZd iz.kkyh dks ySECMk& lkbyksfFkzu lokZf/kd izHkkfor djrk gSA serotorin-2A fjlIVlZ dk ySECMk lkbyksfFkzudh efLr"d fo"kkDrrk esa Hkkxhnkjh ds ckjs esa Hkh lq>ko bu ifj.kkeksa }kjk feyrk gSA ifj.kke iqu% ckr dk ladsr nssrs gS fd efLr"d O;ogkj lEcfU/kr ifjorZu vkxs tkjh jgrk gS ;fn ySECMk & lkbyksfFkzu dk izn'kZu tksf[ke tkjh jgrk gSA
valkjh rFkk vU;( VkWfDldksykWth ysVlZ( 2012( 211(1&9
 QksVksebØksxzk¶l vkQ jSV dksjil LVªkb,Ve lsD'kUl bYylVªsfVax bQsDV vkWu n Vkbjkslhu gkbMªkslkbyst bEe;wuksfV,dfVfoVh QkWyksbax iksLV&ySDVs'kuy ,Dlikstj vkWQ jSV~l Vw ySEcMk&lkbysfFkzu jSV~l oj ,DliksTM+ Vw ySEcMk&lkbyksfFkzu ¼a1-0,e-th-@ds-th-vkj 3-0 ,e-th-@ds-th- ckWMh osV@Ms½ Ýkse iksLV&ySDVs'kuy Ms ihMh 22 Vw ih Mh49] bQsDV vkWu Vkbjkslhu gkbMªkslkbyst+ bEe;wuksfj,dfVfoVh LVMhM 28 Mst vkWQVj ,Dlikstj vkWQ ySEcMk lkbyksfFkzu vkWu ih Mh50] Ldsy ckj=300 ekbØks ehVj |