gkWfVaxVu fodkj ,d ykbykt Luk;fod fodkj gS tks fd gkWfVaxVu izksVhu esa XywVkekbu dks vlkekU; :i ls nksgjkus dh otg ls mRiUu gksrk gSA orZeku v/;;u ls ge gkWfVaxVu jksx esa fu;fer VªkaUlM;wlj CREB izksVhu xfrfof/k (TORCs) dk v/;;u djsaxsA TORCs VªkUlfØIluy lgfu;ked ijvkWDlhlkse izksfyQjsVj lfØ; fjlsIVj xkek dksvDVhosVj& 1a (PGC-1a) dh vfHkO;fDr esa ,d egRoiw.kZ Hkwfedk fuHkkrs gSA ftudh vfHkO;fDr gkWfVaxVu jksx esa fcxM+h gqbZ gSA geus ik;k gS fd STHdhQ111 dksf'kdkvksa esa TORCI vfHkO;fDr Lrj esa deh vkbZ tks fd mRifjorhZ Htt dks ,u,y,l&N171 - 82Q ds fLVª,Ve] 2/R6 vkSj HdhQ111HD VªkUltsfud pwgksa esa vkS LVªs;Vy Årdksa ¼'koijh{kk ls izkIr½ gkWfVaxVu jksxh ls izkIr gksrk gSA TORCI (WT) vfHkO;fDr taxyh izdkj vkSj Htt LVªkbVy dksf'kdkvksa esa] CREBmRNA esa rFkk izksVhu Lrj eas] PGC-1a izkseksVj xfrfof/k PGC-1a dh mRNA vfHkO;fDr NRF-1, Tfam rFkk cytc thu] ekbVksdk.fMª;y Mh,u, lkexzh] ukbVksdkofMª;y xfrfof/k vkSj ekbVksdk.fMª;y f>Yyh {kerk TORC1 vfHkO;fDr LVªkbVy dksf'kdkvksa dh 3&ukbVªksizksikbvksfud vEy&e/;LFk fo"kkDrk dks c<+k nsrk gSA dYpj dh jkbZ WT rFkk mRifjorhZ Htt LVªkbVy dksf'kdkvksa esa ,d NksVk gs;jfiu vkj-,u-,- e/;LFk TORCI ds fiNM+us ds dkj.k PGC-1a vfHkO;fDr fiNM+ tkrh gS rFkk 3-NP izsfjr fo"kkDrk dks laosnu'khyrk c<+ tkrk gSA PGC-1a dh vfrvfHkO;fDr TORCI e/;LFk Htt LbVªkbVy dksf'kdkvksa dh laosnu'khyrk dks c<+krh gSA TORCI dk LVªkfV;e NLS-N171-182Q gkWfVaxu jksx Vªkaltsfud pwgksa esa U;wjks fMtsujs'ku dks izsfjr djrh gSA vUr esa Htt dks iNkM+uk TORCI vkSj Htt striatal dksf'kdkvksa esa CREB dks vfHkO;fDr dks jksdrk gSA ;s fu"d"kZ crkrs gS fd TORCI dh v'kDr vfHkO;fDr o dk;Z ds dkj.k PGC-1a esa deh gks tkrh gSA tks fd ekbVksdkfUMª;k ds gkWfVaxVu fodkj esa vfØ;k'khyrk dks iznf'kZr djrk gSA

prqosZnh rFkk vU;] ekuo vkf.od vkuqoaf'kdh 21]3474&3488]2012